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It produced the same outcome as their October 26 matchup at MSU's Hammons Center Pool, with the exception that Drury this time outpointed the Bears 258-228 in combined scores (as compared to their 270-214 deficit in the earlier matchup).
"Overall it was great to see our girls rise up and swim consistently well throughout the meet and win as big as they did tonight," Drury coach Brian Reynolds said. "Obviously on the men's side, we kept losing all the close touches and that just continued to mount and spiral on us. They had the better on the close races ... I think the meet was closer than the final score reflected.
"I can't be disappointed knowing the level of training we've been doing of late and the sheer volume of kicking work we've really ramped up in the last few days ... you could see our legs dying at the end of races, and that cost us in the close races. We'll just have to see if the hard training in January is a payoff for us at the end (at nationals). Time will tell."
Drury won 9 of the 11 women's races and split the two diving events - including a victory by freshman Rebekah Laupp on the 3-meter board - to push their all-time series mark to 11-3 against the Bears. Drury now leads the men's series by a 14-12 count.
Panther individual victories came from Sarah Pullen in the 1000 Free, Tiffany Bell in the 200 Free and 100 Free, Wai Ting Yu in the 50 Free, Katia Alyabyeva in the 200 IM, Jacquelyn Haines in the 100 Fly and Molly Brown in the 100 Back.
The MSU men, meanwhile, took 7 of the 11 races and claimed both diving boards.
Wins for the DU men individually came from Ryan Arabejo in the 1000 Free and 500 Free and newcomer Stanislav Kuzmin in the 100 Fly.
Missouri State broke open a tight meet midway through with a 1-2-3-4 finish in the 200 IM, and the eight-time defending NCAA-II national champion Panthers were forced to try to dig themselves out of a hole from there.
It was Senior Night for DU, in its final home meet, with seven DU men and five Panther women swimmers and divers recognized in pre-meet ceremonies.
Wednesday's "Duel In The Pool" was televised once again by Mediacom Connections 22 for replay showings Thursday, Friday and Saturday nights at 7 p.m.
Drury is back in action on Friday at the University of Missouri for a dual meet in Columbia before heading to Kirksville on Saturday to face Truman State.