Teddy Simniok hit 6 of 7 shots and finished with 15 points while Drake Patterson (5 of 7 from the field) had 13 points and Ian Carter finished with 12 for the Panthers, who improved to 10-4 overall and 4-2 in the GLVC.
Illinois-Springfield - which just a week ago, beat nationally 10th-ranked Southern Indiana - fell to 4-10 and 2-4.
The Panthers led just 12-9 eight minutes into the game before a 17-4 run over the next five minutes gave DU a 29-13 lead on its way to a 35-21 advantage at the halftime break. Eight points from Patterson - including a pair of treys - and a Kameron Bundy 3-pointer keyed the surge.
Drury then pushed the lead as high as 29 points (67-38) with 10:11 left on its way to a second straight victory. The Panthers are 8-1 at The O', where they've won 14 of their last 15 games.
"It was good to get back home," Drury coach Steve Hesser said. "I thought we had spurts of some really good play and I thought overall from the offensive end, other than missing some stuff at the basket in the first half, we played and shared the ball well."
Drury matched a season high with 27 assists, led by seven from Brandon Lockhart and five by Ian Carter. Lockhart also had five of DU's 17 steals, which also equalled a season best.
Drury shot 55 percent (34 of 62) from the field for the game, including 64 percent (21 of 33) in the second half. The Panthers also drained 13 3-pointers (in 27 attempts), including six treys from Hall, as he moved to 307 now for his DU career (second all-time, and now 44 behind leader Matt Miller).
Brandon Snowden had 21 points to lead the Prairie Stars, who outrebounded the Panthers 35-28.
Drury returns home on Saturday to play GLVC West rival Quincy in a 3:15 p.m. tipoff. It's "Great Southern Throwback Day," with the Panthers wearing retro uniforms commemorating the school's 1978-79 NAIA National Championship team and '70s themes and giveaways throughout the day.