On the second play from scrimmage, Alabama’s Eddie Lacy took a hand off from AJ McCarron and scampered 73 yards for the score.
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The Crimson Tide would add two more first quarter touchdowns and another early on in the second quarter to take a commanding 28-0 lead.
Missouri did get a spark coming out of a lightning delay with 8:40 left in the second quarter as Marcus Murphy took the Alabama kick off back 98 yards for the first and only touchdown for the Tigers.
Missouri was able to create two turnovers in the game, but they were for naught as the Alabama defense held strong at every turn.
The Crimson Tide were especially staunch on third downs as Missouri was just 2-for-15 on third down conversions and only had nine total first downs all night compared to 21 for Alabama.
Corbin Berkstresser threw for 126 yards and two interceptions in the game as he filled in for the injured James Franklin. Berkstresser also had six rushes for -50 yards. As a team Missouri had just three yards on the ground against 362 gained by the Alabama running game.
Missouri will be seeking its first SEC win yet again at home against Kentucky next Saturday.